Positron Emission Tomography/Computed Tomography (PET/CT) and Radioimmunotherapy of Head and Neck Cancer Patient Derived Xenografts in NRG Mice with Theranostic [64Cu]Cu-DOTA-Panitumumab F(ab’)2 and [177Lu]Lu-DOTA-Panitumumab F(ab’)2

Mol Pharm. 2025 Nov 3;22(11):6999-7009. doi: 10.1021/acs.molpharmaceut.5c01009. Epub 2025 Oct 21. ABSTRACT Head and neck squamous cell carcinoma (HNSCC) expresses epidermal growth factor receptors (EGFR) in 90% of cases. Here we studied PET/CT imaging of three clinically relevant HNSCC patient…