Eur J Nucl Med Mol Imaging. 2022 Mar;49(4):1113-1126. doi: 10.1007/s00259-021-05564-0. Epub 2021 Oct 8. ABSTRACT PURPOSE: The β¯-emitting terbium-161 also emits conversion and Auger electrons, which are believed to be effective in killing single cancer cells. Terbium-161 was applied with…
Phase I/II Trial of the Combination of 177Lutetium Prostate specific Membrane Antigen 617 and Idronoxil (NOX66) in Men with End-stage Metastatic Castration-resistant Prostate Cancer (LuPIN)
Eur Urol Oncol. 2021 Dec;4(6):963-970. doi: 10.1016/j.euo.2020.07.002. Epub 2020 Aug 3. ABSTRACT BACKGROUND: Trials of lutetium prostate specific membrane antigen (PSMA) in men with metastatic castration-resistant prostate cancer (mCRPC) have demonstrated good safety and efficacy, but combination strategies may improve…
Radioimmunotherapy of human pancreatic cancer xenografts in NOD-scid mice with [64Cu]Cu-NOTA-panitumumab F(ab’)2 alone or combined with radiosensitizing gemcitabine and the PARP inhibitor, rucaparib
Nucl Med Biol. 2020 May-Jun;84-85:46-54. doi: 10.1016/j.nucmedbio.2020.02.001. Epub 2020 Feb 3. ABSTRACT INTRODUCTION: Our objective was to determine the feasibility of extending our previously reported PET imaging study of pancreatic cancer (PnCa) with Cu-NOTA-panitumumab F(ab’)2 to radioimmunotherapy (RIT) by exploiting…
Treatment of Orthotopic U251 Human Glioblastoma Multiforme Tumors in NRG Mice by Convection-Enhanced Delivery of Gold Nanoparticles Labeled with the β-Particle-Emitting Radionuclide, 177Lu
Mol Pharm. 2023 Jan 2;20(1):582-592. doi: 10.1021/acs.molpharmaceut.2c00815. Epub 2022 Dec 14. ABSTRACT In this study, we investigated convection-enhanced delivery (CED) of 23 ± 3 nm gold nanoparticles (AuNPs) labeled with the β-particle-emitting radionuclide 177Lu (177Lu-AuNPs) for treatment of orthotopic U251-Luc…
The association between lesion tracer uptake on 68Ga-DOTATATE PET with morphological response to 177Lu-DOTATATE therapy in patients with progressive metastatic neuroendocrine tumors
Nucl Med Commun. 2022 Jan 1;43(1):73-77. doi: 10.1097/MNM.0000000000001488. ABSTRACT PURPOSE: To determine in a group of patients with progressive metastatic neuroendocrine tumors (PM-NETs) treated with 177Lu-DOTATATE whether a correlation exists between somatostatin receptor (SSTR)-2 expression in various tumors on baseline…
The role of [18F]-DCFPyL PET/MRI radiomics for pathological grade group prediction in prostate cancer
Eur J Nucl Med Mol Imaging. 2023 Feb 21. doi: 10.1007/s00259-023-06136-0. Online ahead of print. ABSTRACT PURPOSE: To evaluate the diagnostic accuracy of -DCFPyL PET/MRI radiomics for the prediction of pathological grade group in prostate cancer (PCa) in therapy-naïve patients.…
The role of [18F]-DCFPyL PET/MRI radiomics for pathological grade group prediction in prostate cancer
Eur J Nucl Med Mol Imaging. 2023 Feb 21. doi: 10.1007/s00259-023-06136-0. Online ahead of print. ABSTRACT PURPOSE: To evaluate the diagnostic accuracy of -DCFPyL PET/MRI radiomics for the prediction of pathological grade group in prostate cancer (PCa) in therapy-naïve patients.…
18F-DCFPyL PET/CT in advanced high-grade epithelial ovarian cancer: A prospective pilot study
Front Oncol. 2022 Oct 13;12:1025475. doi: 10.3389/fonc.2022.1025475. eCollection 2022. ABSTRACT OBJECTIVES: Glutamate carboxypeptidase-II (GCP-II), a zinc metalloenzyme that resides in cell membrane, has been reported as overexpressed in the neovasculature of ovarian cancers. The study objective was to determine whether…
18F-DCFPyL PET/CT in advanced high-grade epithelial ovarian cancer: A prospective pilot study
Front Oncol. 2022 Oct 13;12:1025475. doi: 10.3389/fonc.2022.1025475. eCollection 2022. ABSTRACT OBJECTIVES: Glutamate carboxypeptidase-II (GCP-II), a zinc metalloenzyme that resides in cell membrane, has been reported as overexpressed in the neovasculature of ovarian cancers. The study objective was to determine whether…
Extended Results and Independent Validation of a Phase 2 Trial of Metastasis Directed Therapy for Molecularly Defined Oligometastatic Prostate Cancer
Int J Radiat Oncol Biol Phys. 2022 Aug 25:S0360-3016(22)00644-7. doi: 10.1016/j.ijrobp.2022.06.080. Online ahead of print. ABSTRACT PURPOSE: The role of metastasis-directed therapy (MDT) in molecularly defined oligorecurrent prostate cancer (PCa) remains irresolute. We present extended follow-up and an independent validation…